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Psychedelic Medicine in Real de Catorce, Mexico.

We invite you to be part of this extraordinary experience under the starry sky in the ancient desert of Wirikuta, in the company of Grandfather Fire and peyote, in a traditional ceremony guided by our marakame. This retreat offers you the opportunity to meet yourself again, treat yourself gently, and find peace beyond the pain that leaves scars on the soul.

Retreat Highlights

  • Maximum 6 participants per retreat
  • Transfer from San Luis Potosi airport to Real de Catorce
  • 2–4 preparation sessions: 3 online and one on site before the ceremony
  • 5–10 integration sessions: 2-3 onsite after the ceremonies
  • Tour to the Wirikuta desert and the ghost town
 
  • 7 days and 6 nights in Real de Catorce, Mexico
  • An extraordinary experience in the heart of Wixarika desert
  • 2 ceremonies with peyote (mescaline) with a marakame (Huichol shaman)
  • Luxury rooms with private bathroom
  • Breathwork, yoga, meditation, ice bath, and more
 

PEYOTE RETREAT

Real de Catorce, México

Real de Catorce is a magical town in the mountains at an altitude of 2,750 meters above sea level. The climate is cold, semi-arid, or steppe-like, with temperatures ranging from 35°C to -10°C. It is a small village where Wixarika, Mexicans and internationals live together in an intertwined way.

Day 1 - Welcome & Grounding

Participants will be picked up at San Luis Potosí Airport, arriving in the afternoon/evening to Real de Catorce. Upon arrival, guests will be welcomed by the retreat team, have time to settle in, and connect with other attendees while enjoying snacks and drinks.

Participants’ vital signs will be assessed, and they will have the opportunity to meet the marakame (shaman), therapists, coaches, and staff. Dinner will take place at one of the town’s restaurants, followed by a nighttime walk in Real de Catorce where, in winter, you can see the Milky Way in the night sky.

Day 2 - Preparation and Alignment

We start the day with a breathwork session, followed by an ice plunge and yoga. This is followed by a nutritious breakfast that begins to prepare the body for the sacred medicine experience. Afterwards there will be a workshop to create the tzicuri (God’s eye) that will be used during the ceremonies, and there we will have a presentation about the Wixarika cosmogony.

In the afternoon the participants will have 1:1 preparation sessions with the coaches and therapists and will have the opportunity to spend time with our invited marakame (Shaman), as well as a sunset meditation session followed by dinner and gathering and circle of gratitude.

Day 3 - Awakening ceremony

We’ll start the day with a mindful breathing session, followed by an ice plunge and Qigong, and then continue with a breakfast in accordance with the ceremony’s recommendations. Weather permitting, we’ll go on a peyote hunt in the Wirikuta Desert; otherwise, we’ll hold a workshop on making a Tzicury (a talisman for the ceremony).

After lunch, guests will be able to participate in sessions to prepare for the ceremony, as well as Thai massages, biomagnetism, and binaural therapy. We will arrive at the ceremonial center before sunset.

Preparing the body and mind, as well as watching the sunset, mark the beginning of the ceremony. Once night falls, the ceremony begins and includes 5 shamanic chants and up to 5 doses of peyote. We conclude the ceremony at sunrise.

At this ceremony, our guests have their “aha!” moment; they realize the burdens they’ve been carrying—the traumas, the source of their emotional baggage—and it marks their awakening to a new life.

Day 4 - Rest, reset, and integrate

After a long night, we start the day at noon with optional sessions of yoga, meditation, breathing exercises, and Qigong. We share lunch with the marakame and begin the integration process with one-on-one sessions with the coaches and therapists. In the afternoon, before dinner, we’ll have a group integration session, meditation, a gratitude circle, and immersive cultural activities.

Day 5 - Letting go ceremony

The day begins with meditation, breathing exercises, an ice plunge, and yoga, followed by a nutritious and balanced breakfast as part of the preparation for the second ceremony. Afterward, weather permitting, we will visit Cerro del Quemado, which is the main ritual center of the Wixarika.

The afternoon is a time for personal reflection, decompression, and aligning mind, body, and spirit for the second ceremony. At 10:00 p.m., we’ll head to the ceremonial center, where we’ll begin the ceremony at 10:30 p.m. and conclude at sunrise.

It is during this second ceremony that most of our guests experience a profound purification, freeing themselves from the burdens, responsibilities, and sadness they had been carrying.

Day 6 - Integration beyond the retreat

After a long night, we start the day at noon with optional sessions of yoga, meditation, breathing exercises, and Qigong. We share lunch with the marakame and begin the integration process with one-on-one sessions with the coaches and therapists. In the afternoon, before dinner, we’ll have a group integration session, meditation, and a gratitude circle.

Our guests will be able to participate in private spiritual guidance sessions with our marakame, and they may also choose to participate in a group integration session.

Day 7 - Evolving and Growing

Our last day of the retreat begins with meditation, mindful breathing, an ice plunge, and yoga session. We continue with breakfast and a special session with the coaches or therapists to design a plan for change and integration. We share lunch and come together in a circle of gratitude for our teachers, guides, and support staff. The return trip from Real de Catoce to San Luis Potosí is scheduled from 2:00 p.m. to 5:00 p.m.

Integration is what allows us to create lasting change; that’s why you don’t leave alone—you take home a toolkit and the opportunity to schedule 10 online integration sessions with your coach or therapist.

Initial interview

The initial interview is to learn your objectives for the entheogenic or psychedelic experience, and to address any questions you may have about the retreat, the participants, or logistics.

Assessment

The Assessment may be through an in-person interview, or online interview. Our aim is to know whether you are physically, emotionally and mentally fit to participate in the retreat, and to identify any pre-existing conditions that are incompatible with the use of the psychedelic medicine.

Confirmation

Our team will send you a confirmation email with detailed information for the retreat — payment methods, location, weather, rooms, what you should pack — and will also send the contract documents, informed consent, and emergency contact.

Preparation

Before the retreat you will have the option to schedule up to 4 preparation sessions with our team. Depending on your objectives we will assign you a coach or a therapist in your language, with whom you can establish your goals and prepare for the retreat.

Retreat

The retreat is 7 days and 6 nights in high-end accommodations in the municipality of Real de Catorce in Mexico. It includes two ceremonies with entheogens with the support of traditional doctors, coaches, and therapists.

Integration

Integration begins after the first ceremony; our team will support you to process the experience and integrate it appropriately in order to obtain the greatest benefit from the psychedelic experience. After the retreat you will have the opportunity to schedule up to 10 integration sessions in the 3 months following the retreat.

Mescaline is a naturally occurring psychedelic alkaloid, a phenethylamine, found mainly in the peyote cactus (Lophophora williamsii) and other cacti such as San Pedro, traditionally used in shamanic rituals for its visionary effects. Mescaline’s mechanism of action is based on its binding to adrenergic receptors, especially serotonergic ones, for which it is an agonist. Specifically, there are several types of these receptors that participate in the generation of hallucination.

Peyote has been used by the Huichol (Wixarika) for millennia and is a fundamental part of their worldview and way of life. Each year ritual pilgrimages are made from the coast of Jalisco and Nayarit to Cerro del Quemado in Real de Catorce, S.L.P., where they carry out their traditional ceremonies. In 2025 UNESCO declared the Wixarika sacred route a cultural heritage of humanity.

Psychedelic Medicine in Real de Catorce, Mexico.

We invite you to be part of this extraordinary experience under the starry sky in the ancient desert of Wirikuta, in the company of Grandfather Fire and peyote, in a traditional ceremony guided by our marakame. This retreat offers you the opportunity to meet yourself again, treat yourself gently, and find peace beyond the pain that leaves scars on the soul.

Retreat Highlights

  • Maximum 6 participants per retreat
  • Transfer from San Luis Potosi airport to Real de Catorce
  • 2–4 preparation sessions: 3 online and one on site before the ceremony
  • 5–10 integration sessions: 2-3 onsite after the ceremonies
  • Tour to the Wirikuta desert and the ghost town
  • 7 days and 6 nights in Real de Catorce, Mexico
  • An extraordinary experience in the heart of Wixarika desert
  • 2 ceremonies with peyote (mescaline) with a marakame (Huichol shaman)
  • Luxury rooms with private bathroom
  • Breathwork, yoga, meditation, ice bath, and more
 

PEYOTE RETREAT

Real de Catorce, México

Real de Catorce is a magical town in the mountains at an altitude of 2,750 meters above sea level. The climate is cold, semi-arid, or steppe-like, with temperatures ranging from 35°C to -10°C. It is a small village where Wixarika, Mexicans and internationals live together in an intertwined way.

Day 1 
Welcome & Grounding

Participants will be picked up at San Luis Potosí Airport, arriving in the afternoon/evening to Real de Catorce. Upon arrival, guests will be welcomed by the retreat team, have time to settle in, and connect with other attendees while enjoying snacks and drinks.

Participants’ vital signs will be assessed, and they will have the opportunity to meet the marakame (shaman), therapists, coaches, and staff. Dinner will take place at one of the town’s restaurants, followed by a nighttime walk in Real de Catorce where, in winter, you can see the Milky Way in the night sky.

Day 2 
Preparation and Alignment

We start the day with a breathwork session, followed by an ice plunge and yoga. This is followed by a nutritious breakfast that begins to prepare the body for the sacred medicine experience. Afterwards there will be a workshop to create the tzicuri (God’s eye) that will be used during the ceremonies, and there we will have a presentation about the Wixarika cosmogony.

In the afternoon the participants will have 1:1 preparation sessions with the coaches and therapists and will have the opportunity to spend time with our invited marakame (Shaman), as well as a sunset meditation session followed by dinner and gathering and circle of gratitude.

Day 3
Awakening ceremony

We’ll start the day with a mindful breathing session, followed by an ice plunge and Qigong, and then continue with a breakfast in accordance with the ceremony’s recommendations. Weather permitting, we’ll go on a peyote hunt in the Wirikuta Desert; otherwise, we’ll hold a workshop on making a Tzicury (a talisman for the ceremony).

After lunch, guests will be able to participate in sessions to prepare for the ceremony, as well as Thai massages, biomagnetism, and binaural therapy. We will arrive at the ceremonial center before sunset.

Preparing the body and mind, as well as watching the sunset, mark the beginning of the ceremony. Once night falls, the ceremony begins and includes 5 shamanic chants and up to 5 doses of peyote. We conclude the ceremony at sunrise.

At this ceremony, our guests have their “aha!” moment; they realize the burdens they’ve been carrying—the traumas, the source of their emotional baggage—and it marks their awakening to a new life.

Day 4
Rest, reset, and integrate

After a long night, we start the day at noon with optional sessions of yoga, meditation, breathing exercises, and Qigong. We share lunch with the marakame and begin the integration process with one-on-one sessions with the coaches and therapists. In the afternoon, before dinner, we’ll have a group integration session, meditation, a gratitude circle, and immersive cultural activities.

Day 5
Letting go ceremony

The day begins with meditation, breathing exercises, an ice plunge, and yoga, followed by a nutritious and balanced breakfast as part of the preparation for the second ceremony. Afterward, weather permitting, we will visit Cerro del Quemado, which is the main ritual center of the Wixarika.

The afternoon is a time for personal reflection, decompression, and aligning mind, body, and spirit for the second ceremony. At 10:00 p.m., we’ll head to the ceremonial center, where we’ll begin the ceremony at 10:30 p.m. and conclude at sunrise.

It is during this second ceremony that most of our guests experience a profound purification, freeing themselves from the burdens, responsibilities, and sadness they had been carrying.

Day 6
Integration beyond the retreat

After a long night, we start the day at noon with optional sessions of yoga, meditation, breathing exercises, and Qigong. We share lunch with the marakame and begin the integration process with one-on-one sessions with the coaches and therapists. In the afternoon, before dinner, we’ll have a group integration session, meditation, and a gratitude circle.

Our guests will be able to participate in private spiritual guidance sessions with our marakame, and they may also choose to participate in a group integration session.

Day 7
Evolving and Growing

Our last day of the retreat begins with meditation, mindful breathing, an ice plunge, and yoga session. We continue with breakfast and a special session with the coaches or therapists to design a plan for change and integration. We share lunch and come together in a circle of gratitude for our teachers, guides, and support staff. The return trip from Real de Catoce to San Luis Potosí is scheduled from 2:00 p.m. to 5:00 p.m.

Integration is what allows us to create lasting change; that’s why you don’t leave alone—you take home a toolkit and the opportunity to schedule 10 online integration sessions with your coach or therapist.

 

Initial interview

The initial interview is to learn your objectives for the entheogenic or psychedelic experience, and to address any questions you may have about the retreat, the participants, or logistics.

Assessment

The Assessment may be through an in-person interview, or online interview. Our aim is to know whether you are physically, emotionally and mentally fit to participate in the retreat, and to identify any pre-existing conditions that are incompatible with the use of the psychedelic medicine.

Confirmation

Our team will send you a confirmation email with detailed information for the retreat — payment methods, location, weather, rooms, what you should pack — and will also send the contract documents, informed consent, and emergency contact.

Preparation

Before the retreat you will have the option to schedule up to 4 preparation sessions with our team. Depending on your objectives we will assign you a coach or a therapist in your language, with whom you can establish your goals and prepare for the retreat.

Retreat

The retreat is 7 days and 6 nights in high-end accommodations in the municipality of Real de Catorce in Mexico. It includes two ceremonies with entheogens with the support of traditional doctors, coaches, and therapists.

Integration

Integration begins after the first ceremony; our team will support you to process the experience and integrate it appropriately in order to obtain the greatest benefit from the psychedelic experience. After the retreat you will have the opportunity to schedule up to 10 integration sessions in the 3 months following the retreat.

Mescaline is a naturally occurring psychedelic alkaloid, a phenethylamine, found mainly in the peyote cactus (Lophophora williamsii) and other cacti such as San Pedro, traditionally used in shamanic rituals for its visionary effects. Mescaline’s mechanism of action is based on its binding to adrenergic receptors, especially serotonergic ones, for which it is an agonist. Specifically, there are several types of these receptors that participate in the generation of hallucination.

Peyote has been used by the Huichol (Wixarika) for millennia and is a fundamental part of their worldview and way of life. Each year ritual pilgrimages are made from the coast of Jalisco and Nayarit to Cerro del Quemado in Real de Catorce, S.L.P., where they carry out their traditional ceremonies. In 2025 UNESCO declared the Wixarika sacred route a cultural heritage of humanity.

Disclaimer: To offer a unique, authentic, exclusive, and unforgettable experience, our psychedelic medicine retreats are 100% legal and are carried out in collaboration with our partner Nierika MX: Center for Research and Conservation of Traditional Medicine. The retreats comply with the regulations established in the General Health Law, the Federal Law for the Protection of the Cultural Heritage of Indigenous and Afro-Mexican Peoples and Communities, and other applicable provisions. Learn more about Nierika MX.